Differential expression of viral pathogen-associated molecular pattern receptors mRNA in Egyptian chronic hepatitis C virus patients

Abstract Background One possible mechanism utilized by hepatitis C virus (HCV) to escape from the host’s innate immune surveillance is modification of its pathogen-associated molecular patterns (PAMPs) altering or hiding RNA which interfering with toll-like receptors (TLRs) signaling and ultimately hindering production proinflammatory cytokines, chemokines, interferons (IFNs). This study aimed examine expression levels TLR3, TLR7, IFN-α investigate correlated pattern among them in chronic HCV patients. Patients included this were categorized into two different groups, non-treated patients treated patients, addition healthy volunteers as a control group. The blood samples assessed for HCVAb, HCVRNA, genotypes, biochemical analyses. mRNA peripheral quantitatively measured comparison controls. Results significantly downregulated compared both subjects. On other hand, showed non-significant downregulation same three sensing (TLR3, IFN-α) Obviously, positively TLR3 TLR7. Conclusion exhausted immunity against may correlate TLR7 on cells subsequent decrease INF-α possibility targeting these enhance response clear infection needs further studies.